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Drug Incompatibility


Incompatibility is an undesirable reaction that occurs between the drug and the solution, container or another drug. The two types of incompatibilities associated with intravenous administration are physical and chemical [1][2].

Definition of interactions

A drug interaction describes the alteration of a drug effect due to the influence of another substance (i.e. drug, chemical substance, nutrition) resulting in a solution that is no longer optimal for the patient after the substances are mixed1,3.

Chemical precipitation of Midazolam (turbidity) and Ketamin (particle formation)4.

Physical precipitation of Midazolam as a result of an unfavorable pH medium5

Physical incompatibilities of Diazepam. Picture by courtesy of
F. Schröder, Pharmacist Bremen, Germany.

Precipitation of Midazolam (Turbidity). Picture by courtesy of
F. Schröder, Pharmacist Bremen, Germany.


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1 Josephson 2006, RCN 2005, Douglas et al. 2001

2 Craven et al. 2007a, Josephson 2006, Douglas et al. 2001, Nemec et al. 2008

To read the abstract go to the literature page.